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Two main strategies have been used to modify the sequences of semaglutide and tirzepatide (red circles) and increase their bioavailability: 1) removal of the DPP-4 cleavage site, replacing alanine with an analogous molecule (-aminoisobutyric acid (Aib)), but not recognized by the enzyme

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You've probably also heard of its more famous (and more intense) successor, Melanotan 2 MT2 10mg

Longer half-life than native IGF-1 due to reduced binding protein affinity