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Compared with normal renal function, the estimated ratio of the mean AUC 0 was 1.23 (90% confidence interval [CI], 0.911.66) in mild impairment, 1.18 (0.871.59) in moderate impairment and 1.21 (0.871.68) in severe impairment

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Nanna MG, Kolkailah AA, Page C, Peterson ED, Navar AM

3 In 2023, Zhu et al

Similar concentrations have resulted in reduced mTOR activity in canine tumor cells.[52] Though rapamycin has previously been administered to dogs in other studies, this study is unique in the duration of treatment with a lower dose than previously described

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