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Ipamorelins about 2-hour half-life , substantially longer than the 1560 minute half-life of first-generation hexapeptide GH secretagogues , reflects the proteolytic stability conferred by the Aib1 N-terminal residue and the D-amino acid substitutions at positions 3 and 4, providing an intermediate pharmacokinetic profile between short-acting first-generation GH secretagogues and the long-acting GHRH analogue CJC-1295 With DAC

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Water retention via enhanced sodium reabsorption manifests as rapid weight gain and potential blood pressure elevation

Kamermans A, Rijnsburger M, Chakraborty A, van der Pol S, de Vries HE, van Horssen J

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