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The European Medicines Agency (EMA) and Heads of Medicines Agencies (HMA) have published recommendations in tackling the shortages, warning patients that the medications should only be obtained with a prescription and through a pharmacist, cautioning against online purchases except from trusted sources, where there is proper medical supervision (EMA 2024

The right maintenance dose is the one that produces consistent results with tolerable side effects

The details of these findings may differ depending on a patients specific health conditions

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Another study in the Journal of the American Medical Association notes that among those with diabetic nephropathy (loss of kidney function due to diabetes), combining vitamin B6 (25 mg) and folic acid (2.5 mg) (B-complex vitamin) with 1,000 mcg of oral B12 per day for six years increases the risk of cardiovascular events, including heart attack and stroke

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