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Footnotes Author contributions All authors meet the criteria set forth by the International Committee of Medical Journal Editors

Thus, these agents may be less likely to cause false-positives

Adiponectin stimulates apolipoprotein A-1 gene expression in HepG2 cells via AMPK, PPAR, and LXRs signaling mechanisms

Mechanism: DCA is a cytolytic agent that directly disrupts fat cell membranes , leading to cell death (adipocytolysis)

Close observation, correct dosage adjustment, and lifestyle guidance can significantly reduce side effects and optimize the long-term benefits of treatment