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Liraglutide protects cardiac microvascular endothelial cells against hypoxia/reoxygenation injury through the suppression of the SR-Ca(2+)-XO-ROS axis via activation of the GLP-1R/PI3K/Akt/survivin pathways

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Supplementing with B12, or using a tirzepatide and B12 combination , addresses this potential deficiency proactively

The SUSTAIN clinical trial program included thousands of participants and demonstrated both efficacy and safety over extended periods