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However, the efficiency of BBB crossing in humans is not precisely known

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In an imiquimod-induced PsOs-like mouse model, oral administration of proanthocyanidins significantly alleviated skin lesions, reduced epidermal hyperplasia, and decreased inflammatory cell infiltration

Similarly, suppression of Acl mRNA by 90% and ACL activity by 95% had no impact on GSIS in the INS-1 832/13 cell line and in isolated rat islets [53]