[366]revealed that glycyrrhizin can prevent ferroptosis in animal models by regulating iron levels, the GSH/GPX4 pathway, and the NRF2/HO-1/HMGB1 pathway
These data support a hypothesis that the T and C allelic variants of the GPX4 gene differ in their capacity to promote selenocysteine incorporation into GPX4, thereby the polymorphism influences an expression and concentration of the enzyme
Sci Transl Med (2019) 11(478):eaau5758
Common side effects: Gastrointestinal (nausea, diarrhea, vomiting, constipation) typically mildtomoderate and dosedependent
Human umbilical cord mesenchymal stem cell-derived exosomes provide neuroprotection in traumatic brain injury through the LncRNA TUBB6/Nrf2 pathway
Phosphodiesterase type 5 (PDE5) inhibitors (PDE5i) are known for their ability to enhance blood flow and vascular stability and are widely used to treat conditions such as erectile dysfunction, pulmonary hypertension, heart failure, and cancer