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Greater Weight Loss Clinical Trial Data: In the Phase 2 TRIUMPH-1 study , retatrutide achieved unprecedented levels of weight loss : Up to 24.2% average total body weight loss at 48 weeks Over 26% weight loss at the highest dose (12 mg weekly) In comparison: Tirzepatides weight loss peaked at about 22.5% in SURMOUNT-1 at 72 weeks This suggests faster, more significant fat loss in less time with retatrutide
Additionally, it is now known that pro-inflammatory cytokines also hijack IGF-1 intracellular signalling by phosphorylating serine residues on insulin related substrate (IRS) molecules and hence impeding their binding to IGF-1R [124]
OCR values were normalized to cell number
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