A combination of 0.6% nisin and 1% chitosan was shown to inhibit the growth and biofilm formation of Shewanella putrefaciens and Shewanella algae, thereby reducing the accumulation of TVB-N, cadaverine, and other spoilage products in aquatic products 118
The Drug Affinity Complex (DAC) modification adds a lysine-maleimide conjugate that covalently binds serum albumin, extending half-life from roughly 30 minutes (no DAC) to approximately 6 to 8 days (with DAC)
Most stability data supports up to 48 hours at room temperature without significant degradation
(4) active infection requiring antibiotic use
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