However, studies were not included if participants completed other interventions together with diet or exercise, such as bariatric surgery or pharmacological treatment
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Abbreviations ALT: Alanine transaminase AST: Aspartate transaminase AUC 0- : Area under the concentration-time curve BMI: Body mass index C max : Peak plasma concentration CTCAE: Common Terminology Criteria for Adverse Events CYP: Cytochrome P450 GLP-1: Glucagon-like peptide-1 HbA1c: Glycated hemoglobin SU: Sulfonylurea T-Bil: Total bilirubin References Kawamori R, Kaku K, Hanafusa T, Kashiwabara D, Kageyama S, Hotta N
Rates of treatment discontinuationmost commonly from gastrointestinal symptomswere higher, at 6 to 10 percent, depending on the dose, for those who received the pill, compared with a rate of 4 percent for those who received the placebo
Cell Death Dis (2019) 10(4):317