In the TRIUMPH-4 trial , published by Eli Lilly in December 2025, participants taking the 12 mg dose lost an average of 28.7% of their body weight at 68 weeks , and WOMAC pain scores were reduced significantly
Furthermore, the stimulation of the endothelium, results in nitric oxide increases, and oxidative stress lowers for antiatherogenic and anti-inflammatory effects
Studies demonstrated significant reductions in visceral adipose tissue (VAT) within 6 to 12 weeks of consistent daily administration, with effects maintained for the duration of treatment
Retatrutide has been associated with greater increases in resting heart rate compared to tirzepatide
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