Candidate SARS-CoV vaccines formulated with either alum, CpG or Advax (a delta inulin-based adjuvant) found that while the Th2-biased responses associated with alum drove lung eosinophilic immunopathology in mice, protection without immunopathology and a more balanced Th1/Th2 response were induced by Advax 62
Tajik N, Frech M, Schulz O, Schlter F, Lucas S, Azizov V, Drholz K, Steffen F, Omata Y, Rings A, Bertog M, Rizzo A, Iljazovic A, Basic M, Kleyer A, Culemann S, Krnke G, Luo Y, berla K, Gaipl US, Frey B, Strowig T, Sarter K, Bischoff SC, Wirtz S, Caete JD, Ciccia F, Schett G, Zaiss MM
(Yale J Biol Med, 2024), Gwyer et al
Magnesium Ascorbate: Buffered form that's easier to tolerate
Pre-formulated GHK-Cu serums retain 8085% potency at 90 days when refrigerated at 4C, versus 5060% at room temperaturemaking refrigeration essential even for finished cosmetic products
There are side effects and quality issues