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New England Journal of Medicine , 390(8), 701-714

Increase in brain-derived neurotrophic factor expression in early crack cocaine withdrawal

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Semaglutide STEP 1 Trial New England Journal of Medicine (2021) Semaglutide 2.4 mg 14.9% 68 2.4% STEP 2 2 9.6% STEP 4 20 17.4% SELECT Trial (2023) Semaglutide (MACE) 20% Semaglutide HbA1c 2 1.52.0% 36 mmHg LDL-Cholesterol Semaglutide

These differences primarily involve energy metabolism (such as glucose, ketone bodies, glycine, creatinine, and citrate), as well as processes related to the bacterial microbiota (such as TMAO and formic acid) and detoxification (such as hippuric acid)

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