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In research models, AOD9604 has been investigated primarily for its role in lipid metabolism, where it has been shown to influence lipolysis (fat breakdown) and lipogenesis (fat storage)

For example, prolonged stress can influence the stomach's acid production, potentially leading to a reduction in the stomach's ability to properly absorb vitamin B12 from food

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Some protocols split the daily dose into two administrations (morning and evening) to maintain more consistent plasma levels, though definitive human PK data remain sparse as of 2026

The washout allows receptor resensitization while newly formed mitochondria continue operating at baseline