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In summary, the transcriptional inhibition of SCL7A11 leads to reduced antioxidant capacity, the accumulation of ROS, the lack of GPX4, and ferroptosis activation

10.1073/pnas.0507498102 31 NoctorG.MhamdiA.ChaouchS.HanY.NeukermansJ.Marquez-GarciaB.et al

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The changes in GSH levels induced by such stress are instantaneous and drastic processes, while the generation and replenishment of GSH require a lengthy process, due to involving the rate-limiting indicator glutathione synthetase [43]

Organic solvents, including alcohol and its metabolites, are known to impair TJ barriers and emulsifiers present in processed foods can alter the composition of the intestinal microbiota, encouraging bacterial encroachment beyond the mucous layer that may lead to epithelial inflammation and damage (Vojdani 2014