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In cancer patients, a detrimental effect of vitamin D supplementation may be associated with defective VDR signaling, according to data from preclinical studies: VDR deficiency could lead to the loss of vitamin D's beneficial effects and possibly the emergence of harmful effects, such as the upregulation of tumor angiogenesis and suppression of anti-tumor immunity (7377)

Various databases (Medline/PubMed, Scopus, and Web of Science) were systematically searched for relevant English language articles published up to April 2023

The delay in conducting the assays could have contributed to the variability

But a gap in data is not evidence of harm, and every mechanistic signal we have points the other way

BPC-157 is studied for effects on angiogenesis (formation of new micro-blood vessels), tendon-to-bone healing signals, and protection of gastrointestinal mucosa

This broadens the number of pathway and category relationships that may be relevant to the study framework, but it also makes it harder to isolate the contribution of one component