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Instruct patients to inform healthcare providers prior to any planned surgeries or procedures if they are taking ZEPBOUND [see WARNINGS AND PRECAUTIONS ]

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The transport of ions, small water-soluble compounds, and water itself through the paracellular spaces is usually referred to as intestinal permeability. It is measured experimentally or clinically by the use of non- or poorly metabolized, water-soluble marker compounds administered orally and usually measured in the urine in order to calculate the permeability coefficient

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J Agric Food Chem 62:94999506