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Most of the genes downregulated by GLP-1R agonism and GIPR antagonism were associated with neural plasticity and synapse formation, including neuregulin 3 ( Nrg3 ), neurexin 3 ( Nrxn3 ), discs large MAGUK scaffold protein 2 ( Dlg2 ), sodium leak channel, non-selective ( Nalcn ), neurotrimin ( Ntm ), leucine rich repeat and Ig domain containing 2 ( Lingo2 ), leucine rich repeat containing 4C ( Lrrc4c ), interleukin 1 receptor accessory protein like 1 ( Il1rapl1 ) and glutamate ionotropic receptor NMDA type subunit 2B ( Grin2b ) (Fig