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Following injection of lambs with 1mL from 3 weeks of age (at tailing), vitamin B12 levels would be expected to be maintained at adequate concentrations for 180 days (4.5 months), and in some cases up to 200240 days (5-6 months)

Gastrointestinal absorption of vitamin B 12 depends on the presence of sufficient intrinsic factor and calcium ions

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Similarly, we disagree with the applicant and commenters' assertion that the CMS transmittals limit C1831 to lumbar procedures