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Concurrently, advances in genetics and functional genomics have strengthened causal inference by linking peptide pathways to human phenotypes through loss-of-function variants, expression quantitative trait loci, and Mendelian randomization studies

The interface areas of agonist-TMD and ECD-TMD were calculated using FreeSASA 2.0 (ref

Alcohol preferentially becomes the primary fuel source when present, shutting down fat oxidation pathways regardless of peptide signaling

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