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Glucagon-like peptide-1 (GLP-1) receptor agonists are a class of medications primarily used to manage type 2 diabetes and, in some formulations, to support weight management

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The conversation covers how our understanding of obesity as a chronic, relapsing disease has changed over the past 30 years, what the new clinical versus preclinical obesity framework means for how we diagnose and treat it, how GLP-1 drugs work and why they've succeeded where earlier medications failed, what the STEP and SELECT trials revealed about the disease-modifying potential of semaglutide, and how patients and clinicians should be thinking about who these drugs are really for

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