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This triple agonist design differentiates Retatrutide from earlier investigational peptides that primarily targeted one or two metabolic pathways, allowing researchers to explore coordinated endocrine signaling within a single experimental model

They are also not approved by the FDA or any other government agencies 3

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Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial