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Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) receptor agonist used for chronic weight management, along with a reduced calorie diet and increased physical activity, for people with an initial body mass index (BMI) of: 30 kg/m2 or greater (obesity) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, dyslipidemia, obstructive sleep apnea or cardiovascular disease)

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These findings suggest that dose optimization may significantly enhance treatment outcomes across the GLP-1 class ^1

Site rotation: Systematically rotate injection sites between abdomen (at least 2 inches from navel), outer thighs, and upper arms to reduce local irritation and prevent tissue hardening [8]