Maiti A, Muftuoglu M, Ignatz-Hoover JJ, DiNardo CD, Ravandi F, Andreeff M , Xiao L, Huang X, Patel KP, Litten JB, Bourk E, Astrow S, Kantarjian HM, Tomlinson BK, Daver N, and Wald D
However, alternative oxygen concentrations, such as 1% or 5%, were not investigated, leaving it unclear whether the effects observed are specific to the 3% condition or indicative of a more general hypoxia-dependent response
In our experimental condition, HC treatment determined a downregulation of NPC1, a lysosomal cholesterol transporter that facilitates the efflux of cholesterol from the lysosome to the cytoplasm
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C.BuscheT.KalinowskiJ.BourdeauxF.GriningerM.et al (2018)
It has a strong binding ability to GLP-1 receptor and is not easily degraded by DPP-4