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Perhexiline was an effective anti-angina drug used in the last century, but was recalled by the manufacturer because of hepatotoxicity and peripheral neurotoxicity ( CPT1A in NAFLD The global obesity epidemic has dramatically increased the prevalence of non-alcoholic fatty liver disease (NAFLD), with no approved treatment now (Weber et al., 2020)

FIGURE 2 Figure 2 depicts melatonin as a central physiological hub linking the circadian clock, sleep regulation, and redox homeostasis

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