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The thought is that the GLP-1 agonists mechanism of action can lead to pancreatic cell hyperplasia (since the GLP-1 receptors are in the islet beta cells and exocrine duct cells), leading to a back up in pressureand you got it, inflammation

These people's metabolism have been completely shut off for their, much of their lives, you know, and obviously you have to weigh risk versus benefit with your clinician, your, you know, your practitioner, and I encourage everyone to do that

Appl Physiol Nutr Metab (2015) 40(11):112936

Nature 442 , 709712 (2006)

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The combination of natural environmental cold exposure with strategic peptide therapy offers winter athletes a potential performance edge