hrs.2025.107770 Chen SD, Chuang YC, Lin TK, Yang JL (2023) Alternative role of glucagon-like Peptide-1 receptor agonists in neurodegenerative diseases
This observed risk profile likely stems from two pharmacological factors: (1) the contraindication of metformin in patients with renal insufficiency, and (2) the potential dehydrating effects associated with GLP-1 receptor agonists
Microbial dysbiosis leads to an increase in opportunistic pathogens and a reduction in beneficial bacteria, which collectively result in the excessive production of detrimental metabolites, particularly uremic toxins such as indoxyl sulfate and trimethylamine-N-oxide, while concurrently decreasing beneficial metabolites, such as short-chain fatty acids and tryptophan catabolites, including indole-3-aldehyde
It can sound like, What am I going to eat next? Why am I craving something sweet? Should I snack? Did I eat too much? or Why am I thinking about food again when I already ate? For some people, food noise is occasional
These drugs not only affect eating behavior but can also have an impact on emotional behavior and cognitive function due to the presence of receptors for these neurochemical systems in specific areas of the brain
Midttun, G
