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The relationship between Zepbound and bloating appears to be indirect, mediated through the drug's effects on gastric emptying and intestinal transit time rather than a direct toxic effect on the gastrointestinal tract

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Given the central role of ROS homeostasis in health and disease, targeting ROS and their mediated ROS balancing pathways holds great therapeutic potential [556, 557]

Notably, no redox biomarkers were collected in this trial, which limits mechanistic interpretation