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2 Methodology This review was conducted through a literature search in PubMed, Scopus, Web of Science and Google Scholar, using combinations of keywords such as Parkinsons disease, -synuclein aggregation, sirtuins, insulin signaling, GLP-1 and incretin mimetics phytomolecules, neuroprotection, and therapeutics. The search covered publications from 2010 to January 2026

The hypoglycaemia risk arises because IGF-1R cross-activates the insulin receptor at supraphysiologic concentrations, stimulating GLUT4 translocation and glucose uptake [3]

Ding X, Wang T, Shen Y, Wang X, Zhou C, Tian S, et al

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