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In order for B12 to be absorbed from the gut, it requires a specific protein called intrinsic factor (IF)

Instead, experimental evidence suggests that DSIP interacts indirectly with multiple receptor systems, including components of GABAergic, serotonergic, and opioid-associated pathways [1][2]

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At the same time, it decreases 5-hydroxyindole acetic acid (5-HIAA) levels

Given the repression of the proneurogenic bHLH by H3K27me3, it is plausible that histone demethylases could be involved in neuronal fate determination through removal of the H3K27me3 marks and activation of pro-neurogenic bHLH factors

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