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2018 data is from a different population (postmenopausal women not on GLP-1 therapy) using a different dose (5g vs

doi: 10.1182/blood-2004-10-3980 169 MasroriP.Van DammeP

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In such cases, tirzepatide may produce modest glycemic improvement but fall short of achieving target HbA1c levels

Administer intramuscularly using weight-based dosing, with subcutaneous or intravenous administration only when recommended by a veterinarian

It stresses that these effects are not consistent across populations: some patients report improved mood alongside weight loss, while others describe depressive symptoms, anxiety, or emotional blunting