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Malignant cells exhibit marked elevation of redox regulators including Trx1 and GSH, creating therapeutic barriers by neutralizing ROS-mediated cytotoxicity and impairing Fenton reaction-driven ferroptosis (34,69)

CurrTher Res 1985

Sepsis often leads to neurological complications such as delirium and sepsis-associated encephalopathy (SAE), which are linked to increased mortality, prolonged intensive care unit stays, and persistent cognitive impairments (49)

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Key findings were categorized according to disease type, mechanistic pathway, and level of evidence, following PRISMA and SANRA guidance for narrative reviews