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5.1 Peptide YY and the misinterpretation of early tolerability signals Peptide YY (PYY) is secreted postprandially by enteroendocrine L cells and functions as a satiety hormone by activating Y2 receptors in the hypothalamus and brainstem, where it inhibits neuropeptide Ymediated orexigenic signaling (Batterham et al., 2002)
n = 32) treatment group
The magnitude of weight loss observed suggests retatrutide may represent a new benchmark in anti-obesity therapy pending FDA approval
& Bucher, K
June 3, 2025
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