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DMEM with or without H 2 O 2 was introduced into the ATDC5 cell cultures, followed by incubation with varying concentrations of metformin for 24 h to discern the effect of metformin on the cells

The maximum concentrations (C max ) of each dose were 12.3, 48.9, and 141 ng/ml, respectively, and the AUC 0t values were 75.1, 289, and 1930 ng min/ml, respectively