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Research published in major obesity journals demonstrates that approximately 50% of weight lost on GLP-1 therapy returns within 12 months of discontinuation, with some patients gaining back even more due to metabolic adaptation
LncRNAs, typically exceeding 200 nucleotides, not only regulate gene activity near their synthesis site or at distant locations but also act as sponges to bind miRNAs, thereby inhibiting their ability to regulate other target mRNAs
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Recent discoveries have revealed novel regulation of the Hippo pathway, with GLP-1 promoting the nuclear translocation and activation of YAP/TAZ, leading to the activation of regenerative gene programs [29]
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Altogether, these results demonstrate that a selective antibiotic strategy enabled us to identify the specific bacterial taxa associated with GLP-1 levels
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