Among the frontrunners are Semaglutide and Tirzepatide, both widely recognized for their proven efficacy
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Durability of Results: Maintenance Studies: Tirzepatide (SURMOUNT-3): Continued treatment: Additional 5.5% weight loss Stopped treatment: Regained 14% of weight Conclusion: Need ongoing treatment Semaglutide (STEP-4): Continued treatment: Maintained loss, continued losing Stopped treatment: Regained most weight Conclusion: Need ongoing treatment Phentermine: FDA-approved for 12 weeks only Weight regain after stopping is universal Not a long-term solution All Weight Loss Medications: Obesity is chronic disease Medications treat symptoms, dont cure Stopping medication weight regain Long-term or indefinite use necessary for sustained results Safety Profile Comparison: Discontinuation Due to Side Effects: Tirzepatide: 6.2% Semaglutide: 6.9% Liraglutide: 9.9% Naltrexone-bupropion: 25% (very high) Orlistat: 15-20% Phentermine-topiramate: 8-10% GLP-1s have excellent tolerability considering their effectiveness

(Oral semaglutide is also newly approved and available.) Both of these medications reduce appetite and slow digestion, allowing you to eat fewer calories and feel full, resulting in weight loss when theyre paired with healthy habits like a balanced diet and exercise
But the most visible thing may not be the most important thing
Zepbound has since also received approval for obstructive sleep apnea in adults with obesity, expanding its clinical applications