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An early multicenter, randomized, placebo-controlled study in individuals with AD of moderate severity found that supplementation with 2,000 IU/day of all - rac --tocopherol (equivalent to 900 mg/day of RRR --tocopherol) for two years significantly delayed cognitive decline, slowed disease progression, and increased median survival (107)

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Key findings include: HbA1c Reduction: Significant dose-dependent reductions in HbA1c were observed

Activation of the peripheral cholinergic pathway in the enteric nervous system by ghrelin or GHRP-6 might be involved in mediating these effects