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GPR119 as a fat sensor

Nature 481 , 380U166 (2012)

For patients with a diagnosed deficiency, B12 injections may be given daily or weekly during the initial correction phase, then monthly for maintenance

Clinical trials of tirzepatide did not show significant differences in weight loss outcomes based on injection timing within the day

Nearly 3% of British adults are believed to have used a GLP-1 or dual GLP-1/GIP drug in the past year (~1.6 million adults), specifically to support weight loss