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Dysregulation of these pathways contributes to impaired insulin secretion, altered lipid homeostasis, hyperglycemia, and metabolic dysfunction observed in obesity and type 2 diabetes [1]
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The Jastreboff trial demonstrated a 42% relative reduction in hepatic fat content (MRI-PDFF measured) in the 8mg and 12mg retatrutide arms versus 2% with placeboa magnitude not seen with semaglutide or tirzepatide monotherapy in comparable populations
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