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Introduction Cardiovascular diseases, including cardiac arrhythmias, atherosclerosis and heart failure (HF), are diseases of the circulatory system and are a leading cause of morbidity and mortality worldwide (1)

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Mar M, De Gregorio E, De Dios C, Roca-Agujetas V, Cucarull B, Tutusaus A, et al

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Pyroglutamate is a glutamate precursor whose CSF concentration is 120 M (58), rivaling the extracellular glutamine concentration of 400 M (basal glutamate is 2-3 M)

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