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Weight loss from GLP-1s can also reduce or eliminate arthritis, joint pain, or hypertension

For example, wild-type p53 protein induces IGFBP-3 expression, represses the transcription of IGF-II, and suppresses IGF-1R expression (96101)

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Perry T, Greig NH: Enhancing central nervous system endogenous GLP-1 receptor pathways for intervention in Alzheimers disease

Oxidative stress is involved in a variety of neurodegenerative diseases, such as Alzheimers disease (AD), Huntingtons, and Parkinsons diseases [107,108,109], and neurodevelopmental disorders, including ASD [28, 110, 111]