What is GLP-1: They are hormones in the body that modulate insulin, with GLP receptors being found all over the body (brain, pancreas fat, blood vessel walls, skeletal muscle, etc.) These receptors work to make you feel full, decrease appetite, and help release insulin
Unlike the weight loss drugs of ages past, GLP-1 agonists are safe and effective, even long term
neither has been validated in a controlled human trial
GLP-1R is expressed by various populations of central neurons, but it is still not fully clear which specific populations mediate the effects of GLP-1RAs
The article's table puts tirzepatide in a weaker evidence position, with no human lactation data at all versus minimal human data for semaglutide, and describes the usual provider approach as avoiding it
Incretin Hormones Orally ingested glucose stimulates insulin secretion to a greater degree than intravenously administered glucose, a phenomenon labeled the incretin effect