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Although past meta-analyses reported substantial reductions in MACE with DPP-4 inhibitors [23], their conclusions were based on studies with small sample sizes and limited numbers of cardiovascular events, which have not been confirmed by the four CVOTs specifically designed to assess the CV safety of DPP-4 inhibitors

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This interaction site is less defined but comprises the glutathione moiety of Grx(SSG), parts of helix 3, and a conserved lysine/arginine residue that also contributes to the scaffold site 14,15