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Holze C, Michaudel C, Mackowiak C, Haas DA, Benda C, Hubel P, et al

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Notably, controlled fluid flow introduces sustained perfusion and physiologically relevant shear forces, both of which modulate cellular behaviour and allow for a more accurate assessment of nanoparticle transport, distribution and cellular uptake than static in vitro models [175, 176]

Inactivation of iPLA2 in BeWo cells significantly enhanced ferroptosis induction by RSL3

To understand the possible role of this mechanism in the toxicity of metals and of organic compounds at the molecular level, it may be considered that the same endogenous electrophile can be generated in vivo from the bioconversion of the glutathione conjugate of some organic compounds