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Cardiovasc Ther

At the molecular levels, HSCs express the genes which encode for enzymes such as matrix metalloproteinase (MMP)-1 (interstitial collagenase) (Casini et al., 1994), which digests native fibrillar collagen types I and III, and MMP-2 (Milani et al., 1994), which digests denatured collagen types I and III and native collagen type IV, as well as tissue inhibitors of MMPs (TIMP)-1 and TIMP-2 (Iredale et al., 1992)

But is the medication responsible

doi: 10.1016/j.clnesp.2020.03.008

However, observational studies suggest that whilst acute toxicity remains exceptionally rare, sustained very high levels of B12particularly from supplements or injectionsmay be associated with certain health concerns, though these are correlations rather than proven causal relationships

Berberine inhibits ferroptosis and stabilizes atherosclerotic plaque through NRF2/SLC7A11/GPX4 pathway