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Small molecules such as RSL3 and erastin, which primarily target GPX4 and SLC7A11, respectively, demonstrate that impairment of cystine uptake or lipid peroxide detoxification is sufficient to directly trigger ferroptotic cell death

In a similar randomized, double-blind, placebo-controlled clinical trial, Miyanaga et al

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Glutathione is the bodys master antioxidant and cellular protector, vital for detoxification, immune balance, and radiant skin

Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway

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