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They've been through rigorous clinical trials

Immunopathogenic mechanisms of systemic autoimmune disease

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3.5 Sepsis Sepsis is a life-threatening clinical condition arising from an excessive immune response to infection, leading to high morbidity and mortality rates (239)

Two systematic reviews assessing the combined effects of vitamin D and Ca on fractures demonstrated significant reduction in fracture risk in middle-aged to older populations and osteoporotic individuals (46, 78)

The dominant cytomorphology in most cases is that of cells that show some nuclear atypia, namely, regular oval to round nuclear shapes, with moderate anisonucleosis, small nucleoli, and delicate, evenly distributed chromatin