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In the colon, myrosinase produced by the microbiota can catalyze the generation of a wide range of metabolites from glucosinolates, depending on the pH and the presence of cofactors (4, 5)

In macrophages with the M1-like phenotype, arginine is converted into nitric oxide (NO) and citrulline via inducible nitric oxide synthase (iNOS), and this anabolic pathway is closely associated with macrophage cytotoxicity and antitumor effects

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Niacinamide is a type of vitamin B3 that helps improve the skin barrier, control oil production, and lessen pigmentation after acne is niacinamide

Reduced TLR signaling also diminishes cytokine secretion, further weakening the immune response [228]