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These site-specific approaches not only increase the homogeneity of ADCs but also enable novel bio-orthogonal chemistries that utilize reactive moieties other than thiol or amine

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However, there are three SOD metalloisoenzymes, and these isoenzymes display different intracellular and species distributions

Hydroxyls, particularly phenols, are far more prevalent in known payloads than amine moieties, such as -amanitin, tubulysin B, and PNU-15968279, 80, 81

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